EPS1.06 Overproduction of IL-6 and TNF through IRE1α is CFTR genotype dependent
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Propylene-Glycol Aggravates LPS-Induced Sepsis through Production of TNF-α and IL-6
Background : Propylene glycol (1,2-propanediol, PG) is a commonly used solvent for oral, intravenous, as well as topical pharmaceutical preparations. While PG is generally considered to be safe, it has been known that large intravenous doses given over a short period of time can be toxic. Objective: To evaluate the effect of PG in sepsis induced by the bacterial endotoxin lipopolysaccharide (LP...
متن کاملpropylene-glycol aggravates lps-induced sepsis through production of tnf-α and il-6
background : propylene glycol (1,2-propanediol, pg) is a commonly used solvent for oral, intravenous, as well as topical pharmaceutical preparations. while pg is generally considered to be safe, it has been known that large intravenous doses given over a short period of time can be toxic. objective: to evaluate the effect of pg in sepsis induced by the bacterial endotoxin lipopolysaccharide (lp...
متن کاملIL-6 is essential in TNF-a-induced fever
Sundgren-Andersson, Anna K., Pernilla Östlund, and Tamas Bartfai. IL-6 is essential in TNF-a-induced fever. Am. J. Physiol. 275 (Regulatory Integrative Comp. Physiol. 44): R2028–R2034, 1998.—Tumor necrosis factor-a (TNF-a) is a pleiotropic cytokine that orchestrates an array of local and systemic effects. For instance, acute exposure to a high dose of TNF-a results in septic shock and fever. We...
متن کاملIL-6 is essential in TNF-α-induced fever.
Tumor necrosis factor-α (TNF-α) is a pleiotropic cytokine that orchestrates an array of local and systemic effects. For instance, acute exposure to a high dose of TNF-α results in septic shock and fever. We have used interleukin-1β (IL-1β)- and interleukin-6 (IL-6)-deficient mice, along with their wild-type equivalents, to define a role for TNF-α in fever. Briefly, the mice produced prostagland...
متن کاملHaptoglobin 2-2 Genotype Is Associated with TNF-α and IL-6 Levels in Subjects with Obesity
OBJECTIVE To evaluate the association between Haptoglobin (HP) gene polymorphisms with inflammatory status in obese subjects. MATERIALS AND METHODS A cross-sectional study was carried out. A total of 276 apparently healthy men and nonpregnant obese women were enrolled and allocated according to the HP genotype into the HP (1)/HP (1), HP (2)/HP (1), and HP (2)/HP (2) groups. Distribution of HP...
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ژورنال
عنوان ژورنال: Journal of Cystic Fibrosis
سال: 2018
ISSN: 1569-1993
DOI: 10.1016/s1569-1993(18)30237-6